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Redox homeostasis dysregulation in noise-induced hearing loss: oxidative stress and antioxidant treatment | Journal of Otolaryngology - Head & Neck Surgery | Springer Nature Link

TNF-α can stimulate cerebrovascular endothelial cells to express adhesion factors and activate glial cells to produce more inflammatory mediators, thus stimulating the body’s local disease response

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Cells were cultured and treated in a 37 °C humidified incubator gassed with 5% CO 2 and 90% N 2 so as to achieve bone marrow level hypoxia of 5% O 2 or alternatively room air without N 2 to achieve ∼20% O 2