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Diagnostic Criteria The concentration of C0 was measured by MS/MS in the DBS, cutoff values were set as 9.50–57.00 μM, which were adjusted values (considering the probability of missed cases and false negatives on newborn screening) based on 0.5 and 99.5% percentiles among all the samples

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Lack of δ cell inhibition of this α to β paracrine potentiation of insulin secretion likely at least partially explains the excessive nutrient-stimulated insulin secretion observed following the deletion of δ cells or SST [31, 53, 54]