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In a diabetic cardiomyopathy model, ferroptosis interacts with inflammation

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Glucose can be metabolised by two pathways: (i) glycolysis that gives rise to a net of 2 adenosine triphosphate (ATP) and 2 nicotinamide adenine dinucleotide (reduced) (NADH), and (ii) the PPP that gives rise to 2 NADPH and a pentose phosphate sugar moiety that can reenter late glycolysis to fuel the generation of high energy phosphate compounds